Publications

At UNCC:

Danai, L., Ge, E.J., Afonin, K.A. RNA nanoparticles for targeted therapies of triple-negative breast cancers. Molecular Therapy-Nucleic Acids (33), 885-886 (2023).

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2023 and prior:

Pham, V.N., Bruemmer, K.J., Toh, J.D.W., Ge, E.J., Tenney, L., Ward, C.C., Dingler, F.A., Millington, C.L., Garcia-Prieto, C.A., Pulos-Holmes, M.C., Ingolia, N.T., Pontel, L.B., Esteller, M., Patel, K.J., Nomura, D.K., Chang, C.J. Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism. Science. 382(6670), (2023).

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Ge, E.J., Bush, A.I., Casini, A., Chang, C.J., et al.. Connecting copper and cancer: from transition metal signaling to metalloplasia. Nature Reviews Cancer (22), 102-113 (2021).

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Ge, E.J., De La Torre, P., Chang, C.J., ”Chapter 19: Metals in Biology.” Advanced Chemical Biology. Wiley. (2023).

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Toh, J.D.W., Crossley, S.W.M., Bruemmer, K.J. Ge, E.J., He, D., Iovan, D.A., Chang, C.J. Distinct RNA N- demethylation pathways catalyzed by nonheme iron ALKBH5 and FTO enzymes enable regulation of formaldehyde release rates. Proceedings of the National Academy of Sciences 117(41), 25284-25292 (2020).

 

Mashtalir, N.; Dao, H. T.; Sankar, A.; Liu, H.; Corin, A. J.; Bagert, J. D.; Ge, E. J.; DAvino, A. R.; Fil- ipovski, M.; Michel, B. C.; Dann, G. P.; Muir, T. W.; Kadoch, C., Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes. Science, 373 (6552), 306-315 (2021).

 

Leicher, R., Ge, E.J., Reynolds, M.J., Xie, W., Walz, T., Zhang, B., Muir, T.W., Liu, W. Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin. Proceedings of the National Academy of Sciences, 117 (48), 30465-30475 (2020).

 

Ge, E.J., Jani, K.S., Diehl, K.L, Mueller, M.M., Muir, T.W. Nucleation and propagation of heterochromatin by the histone methyltransferase PRC2: geometric constraints and impact of the regulatory subunit JARID2. Journal of the American Chemical Society 141(38), 15029-15039 (2019).

 

Diehl, K.L, Ge, E.J., Jani, K.S., Weinberg, D.N., Allis, C.D., Muir, T.W. PRC2 engages a bivalent H3K27me3- H3K27M dinucleosome inhibitor. Proceedings of the National Academy of Sciences, 116(44), 22152-22157 (2019).

 

Jani, K.S., Jain, S.U., Ge, E.J., Diehl, K.L., Lundgren, S.M., Mueller, M.M., Lewis, P.W., Muir, T.W. The histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase. Proceedings of the National Academy of Sciences, 116(17), 8295-8300 (2019).

 

Wang, X., Paucek, R.D., Gooding, A.R., Brown, Z.Z., Ge, E.J., Muir, T.W., Cech, T.R. Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA. Nature Structural and Molecular Biology 12, 1028-1038 (2017).

 

Oslund, R.C., Su, X., Haughbro, M., Kee, JM., Esposito, M., David, Y., Wang, B., Ge, E.J., Perlman, D.H., Kang, Y., Muir, T.W., Rabinowitz, J.D. Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate. Nature Chemical Biology 10, 1081-1087 (2017).

 

Fang, X., Fu, Y., Long, M.J., Haegele, J.A., Ge., E.J., Parvez, S., Aye, Y. Temporally controlled targeting of 4-hydroxynonenal to specific proteins in living cells. Journal of the American Chemical Society 135, 14496-9 (2013).

 

Jiang, H., Khan, S., Charron, G., He., B., Sebastian, C., Du., J., Kim, R., Ge, E.J., Mostoslavsky, R., Hang, H.C., Hao, Q., Lin, H. SIRT6 regulates TNF-a secretion through hydrolysis of long-chain fatty acyl lysine. Nature 496, 110-3 (2013).